東北大学大学院医学系研究科
血液内科学分野
Department of Hematology, Tohoku University Graduate School of Medicine.
東北大学病院 血液内科
Department of Hematology, Tohoku University Hospital,.

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教室案内

業績

主要論文 2017年

  1. Kobayashi M, Kato H, Hada H, Itoh-Nakadai A, Fujiwara T, Muto A, Inoguchi Y, Ichiyanagi K, Hojo W, Tomosugi N, Sasaki H, Harigae H, Igarashi K. Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency. Haematologica. 2017 Mar;102(3):454-465. doi: 10.3324/haematol.2016.151043.
  2. Saito K, Fujiwara T, Ota U, Hatta S, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Ishizuka M, Tanaka T, Harigae H. Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells. Biochem Biophys Rep. 2017 Jul 13;11:105-111. doi:10.1016/j.bbrep.2017.07.006.
  3. Hasegawa S, Fujiwara T, Okitsu Y, Kato H, Sato Y, Fukuhara N, Onishi Y, Shimizu R, Yamamoto M, Harigae H. Effects of in vivo deletion of GATA2 in bone marrow stromal cells. Exp Hematol. 2017 Dec;56:31-45.e2. doi:10.1016/j.exphem.2017.08.004.
  4. Fujiwara T, Fukuhara N, Ichikawa S, Kobayashi M, Okitsu Y, Onishi Y, Furuyama K, Harigae H. A novel heterozygous ALAS2 mutation in a female with macrocytic sideroblastic anemia resembling myelodysplastic syndrome with ring sideroblasts: a case report and literature review. Ann Hematol. 2017 Nov;96(11):1955-1957. doi:10.1007/s00277-017-3106-7.
  5. Ikeda T, Fujii H, Nose M, Kamogawa Y, Shirai T, Shirota Y, Ishii T, Harigae H. Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity. Arthritis Res Ther. 2017 Aug 11;19(1):187. doi:10.1186/s13075-017-1397-7.
  6. Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H. Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice. Mol Cell Biol. 2017 Jul 14;37(15). pii: e00063-17. doi: 10.1128/MCB.00063-17.
  7. Harigae H. Biology of sideroblastic anemia. Rinsho Ketsueki. 2017;58(4):347-352. doi: 10.11406/rinketsu.58.347.
  8. Fujiwara T, Sasaki K, Saito K, Hatta S, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Harigae H. Forced FOG1 expression in erythroleukemia cells: Induction of erythroid genes and repression of myelo-lymphoid transcription factor PU.1. Biochem Biophys Res Commun. 2017 Apr 1;485(2):380-387. doi:10.1016/j.bbrc.2017.02.068. Epub 2017 Feb 16. PubMed PMID: 28216155.
  9. Inokura K, Fujiwara T, Saito K, Iino T, Hatta S, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Shimoda K, Harigae H. Impact of TET2 deficiency on iron metabolism in erythroblasts. Exp Hematol. 2017 May;49:56-67.e5. doi:10.1016/j.exphem.2017.01.002.
  10. Nasu K, Yamaguchi K, Takanashi T, Tamai K, Sato I, Ine S, Sasaki O, Satoh K, Tanaka N, Tanaka Y, Fukushima T, Harigae H, Sugamura K. Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells. Cancer Sci. 2017 Mar;108(3):435-443. doi: 10.1111/cas.13163.
  11. Shirai T, Fujii H, Saito R, Nasu K, Kamogawa Y, Fukuhara N, Fujita Y, Shirota Y, Ishii T, Harigae H. Relapsing Polychondritis Complicated by Myelodysplastic Syndrome Is Resistant to Immunosuppression: Comment on the Article by Dion et al. Arthritis Rheumatol. 2017 Mar;69(3):682-683. doi: 10.1002/art.39969.
  12. Ichikawa S, Himuro M, Okitsu Y, Fukuhara N, Watanabe M, Hatta S, Kobayashi M, Onishi Y, Matsumoto M, Harigae H. [Successful Treatment of Severe and Refractory Thrombotic Thrombocytopenic Purpura with Early Rituximab Administration]. Nihon Naika Gakkai Zasshi. 2017 Jan;106(1):99-106.
  13. Yokoyama H, Takahashi N, Katsuoka Y, Inomata M, Ito T, Meguro K, Kameoka Y, Tsumanuma R, Murai K, Noji H, Ishizawa K, Ito S, Onishi Y, Harigae H; Tohoku Hematology Forum. Evaluation of the safety and efficacy of recombinant soluble thrombomodulin for patients with disseminated intravascular coagulation associated with acute leukemia: multicenter prospective study by the Tohoku Hematology Forum. Int J Hematol. 2017 May;105(5):606-613. doi:10.1007/s12185-017-2190-8.
  14. Katsushima H, Fukuhara N, Konosu-Fukaya S, Himuro M, Kitawaki Y, Ichikawa S, Ishizawa K, Sasano H, Harigae H, Ichinohasama R. Does double-hit follicular lymphoma with translocations of MYC and BCL2 change the definition of transformation? Leuk Lymphoma. 2018 Mar;59(3):758-762. doi:10.1080/10428194.2017.1357172.
  15. Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H. NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells. Mol Cell Biol. 2017 Sep 12;37(19). pii: e00086-17. doi:10.1128/MCB.00086-17.
  16. Tajima K, Takahashi N, Ishizawa K, Murai K, Akagi T, Noji H, Sasaki O, Wano M, Itoh J, Kato Y, Shichishima T, Harigae H, Ishida Y; Tohoku Hematology Forum. Clinicopathological characteristics of malignant lymphoma in patients with hepatitis C virus infection in the Tohoku district in Eastern Japan. Leuk Lymphoma. 2017 Jun;58(6):1509-1511. doi: 10.1080/10428194.2016.1236376.
  17. Ishii K, Onishi Y, Miyamura N, Fukuhara N, Ishizawa K, Nakanishi M, Ohnaka S, Miyasaka T, Kanno E, Kawakami K, Harigae H, Kaku M. Development and evaluation of a quantitative assay detecting cytomegalovirus transcripts for preemptive therapy in allogeneic hematopoietic stem cell transplant recipients. J Med Virol. 2017 Jul;89(7):1265-1273. doi: 10.1002/jmv.24775.
  18. Muramatsu H, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Takahashi Y, Kanno H, Yamaguchi H, Ohga S, Manabe A, Harigae H, Kunishima S, Ishii E, Kobayashi M, Koike K, Watanabe K, Ito E, Takata M, Yabe M, Ogawa S, Miyano S, Kojima S. Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes. Genet Med. 2017 Jul;19(7):796-802. doi:10.1038/gim.2016.197.
  19. Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M; for National Research Group on Idiopathic Bone Marrow Failure Syndromes. A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study). Am J Hematol. 2017 Dec;92(12):1324-1332. doi: 10.1002/ajh.24905.